研究方向:海洋功能天然产物研究

华东理工大学副教授，博士生导师。中国药科大学药物化学专业博士。以天然功能产物研究为方向，聚焦于活性分子功能筛选作用机制研究和规模化制备。担任生物反应器国家重点实验室植物细胞室负责人，资源与海洋生物工程研究中心课题组组长，承担国家自然科学基金、国家重点研发计划课题、国家重点研发子课题等多个国家级 /省部级项目。在 Acta PharmaceuticaSinica B、Organic Letters、 Plant Journal、 Chinese Chemical Letter专业领域 TOP 期刊等杂志发表论文 30 余篇，申请发明专利 6项,授权 3 项。任上海市学会海洋药物专业委员会秘书。

01 近期发表论文

[1] Ding, Yi; Jiang, Yu; Xu, Sun-Jie; Xin, Xiu-Juan; An, Fa-Liang*, Perpyrrospirone A, an unprecedented hirsutellone peroxide from the marine-derived Penicillium citrinum. Chinese Chemical Letters, 2022.

[2] Zhou, Chen; Yang, Yu-Hui; Tian, Jing-Yi; Wu, Yi-Han; An, Fa-Liang*; Li, Chang-Fu*; Zhang, Yan-Sheng*, 22R- but not 22S-hydroxycholesterol is recruited for diosgenin biosynthesis, Plant Journal, 2022, 109: 940-951.

[3] Yang, Fan; Hua, Qiang; Yao, Li-Gong; Liang, Lin-Fu; Lou, YuXia, Lu, Yan-Hua; An, Fa-Liang*; Guo, Yue-Wei*, One uncommon bis-sesquiterpenoid from the Xisha soft coral Litophyton nigrum, Tetrahedron Letters, 2022, 88: 153571.

[4] Wang Ling-Xu; Zheng Gao-Fan; Xin Xiu-Juan; An, Fa-Liang*, Development of a high-titer culture medium for the production of cholesterol by engineered Saccharomyces cerevisiae and its fed-batch cultivation strategy. Journal of Microbiology and Biotechnology, 2021,32 (1).

[5] Qiu, Xiao-Han; Gong, Li-Zhi; Xin, Xiu-Juan; An, Fa-Liang*, Enhancement of Emodin Production by Medium Optimization and KH₂PO₄ Supplementation in Submerged Fermentation of Marine-Derived Aspergillus Favipes HN4-13, Marine Drugs, 2021,19(8): 421.

[6] Wang, Zhi-Jie; Jiang, Yu; Xin, Xiu-Juan; An, Fa-Liang*, Bioactive indole alkaloids from insect derived endophytic Aspergillus lentulus, Fitoterapia, 2021,153: 104973.

[7] Yang, Fan; Hua, Qiang; Yao, Li-Gong; Liang, Lin-Fu; Lu, Yan-Hua; An, Fa-Liang*; Guo, Yue-Wei*, Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum, Fitoterapia, 2021,151: 104906.

[8] Yang, Jin; Gong, Li-Zhi; Guo, Miao-Miao; Jiang, Yu; Ding, Yi; Wang, Zhi-Jie; Xin, Xiu-Juan; An, Fa-Liang*, Bioactive Indole Diketopiperazine Alkaloids from the Marine Endophytic Fungus Aspergillus sp. YJ191021, Marine Drugs, 2021,19(3): 157.

[9] Ding, Yi; Zhu, Xiao-Jing; Hao, Li-Ling; Zhao, Meng-Yao; Hua, Qiang; An, Fa-Liang*, Bioactive Indolyl Diketopiperazines from the Marine Derived Endophytic Aspergillus versicolor DY180635, Marine drugs, 2020, 18(7): 338.

[10] Zhu, Xiao-Jing; Mao, Yue; Guo, Miao-Miao; Yu, Hai-Yua; Hao, Li-Ling; Hua, Qiang; Lu, Zhi; Hong, Min-Hua; An, Fa-Liang*, Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens, Journal of Bioscience and Bioengineering, 2020,130(5): 457-463.

[11] An, Fa-Liang; Wang, Xiao-Bing; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Bioactive A-ring rearranged limonoids from the root barks of Walsura robusta, Acta Pharmaceutica Sinica B, 2019, 9(3): 545–556.

[12] Ding, Yi (#); An, Fa-Liang(#); Zhu, Xiao-Jing; Yu,Hai-Yuan; Hao, Li-Ling* and Lu, Yan-Hua*, Curdepsidones B–G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus Curvularia sp. IFB-Z10, Marine Drugs, 2019, 17: 266.

[13] An, Fa-Liang; Yin, Yong; Luo, Jun; Kong, Ling-Yi*, Highly oxygenous trichilin-type limonoids from Trichilia sinensis, Chinese Journal of Natural Medicines, 2019, 17(12): 912-917.

[14] An, Fa-Liang; Liu, Wei-He; Zhang, Yi; Tao, Jun; Lu, Yan-Hua*, Spirocurvulaide, a novel spirobicyclic polyketide from a marine fungus Curvularia sp. IFB-Z10, Phytochemistry Letters, 2019, 29: 12-16.

[15] Wei, Xing-Chen; Liu, Chang-Qing; Zhang, Ri-Yu; Zheng, Gao-Fan; An, Fa-Liang *; Lu, Yan-Hua*, Improvement of Curvulamine Production by Precursors Co-addition Strategy in Liquid Culture of Marine-Derived Fungus Curvularia sp. IFB-Z10, Applied Biochemistry and Biotechnology, 2019, 190: 1-17.

[16] Ji, Xiang; Wei, Xing; Qian, Jie; Mo, Xue-Jun; Kai, Guo-Yin; An, Fa-Liang*; Lu, Yan-Hua*, 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K/AKT pathway in BEL-7402/5-FU cells, Food and Chemical Toxicology, 2019, 131: 110533.

02 代表性著作

《植物化妆品学》.中国医药科技出版社,2021.

03 近期主要科研项目

[1] 国家自然科学基金面上项目，41876189，海洋弯孢霉菌丝形态对抗厌氧菌化合物Curvulamine发酵过程的调控及机制研究，2019/01-2022/12，62万，在研，主持

[2] 国家自然科学基金青年基金，81703388，基于HPLC-DAD-MS策略的新颖生物碱二聚体发现及其抗厌氧菌活性研究，2018/01-2020/12，21万，已结题，主持

[3] 重点研发计划项目课题，2018YFC1706206，基于合成生物学的中药成分规模制备及其新变体研究，2018/12-2021/12，324万，已结题，主持

[4] 重点研发计划项目子课题，2018YFC1706201，大黄素等聚酮的合成生物制备体系研究，2018/12-2021/12，72万，已结题，主持

[5] 中国博士后基金特别资助，2018T110359，基于代谢组学方法的DMC逆转多药耐药作用机制研究，2018/07-2020/06，15万，已结题，主持

[6] 上海市青年英才“扬帆计划”，17YF14033700，基于表观遗传调控的新颖抗口腔厌氧菌生物碱的发现，2017/05-2020/04，20万，已结题，主持

04 代表性专利

[1] 安法梁，邱潇涵，弓丽芝，谭仁祥，陈勇。利用海洋真菌黄柄曲霉HN4-13生产大黄素的培养基及其制备方法。申请号：202011525989.X，授权号：CN112481139B

[2] 安法梁，王凌旭，叶蓓，章焰生。利用工程酿酒酵母高效生产胆固醇的发酵培养基及其制备方法。申请号：202110018952.6，授权号：CN112626159B

[3] 安法梁，郑高帆，朱云飞，鞠建华，马俊英。利用深海链霉菌生产怡莱霉素E的培养基及其制备方法。申请号：202110053546.3，授权号：CN112608965B

[4] 安法梁，郑高帆，朱云飞，鞠建华，马俊英。深海链霉菌基因工程突变株生产怡莱霉素E的高产培养基及其规模化发酵工艺。申请号：202210055630.3，公开号：CN114540446A

[5] 洪民华，朱筱婧，冒玥，段天碧，刘丹，安法梁，吕智。一种中草药的发酵方法及发酵产物的应用。申请号：202010182198.5，公开号：CN113398163A

05 荣誉、获奖

[1] 华东理工大学第四届校园新星——科研新星

[2] 上海奉贤区“五美五强”新青年